The activation process always necessarily demands Internet connection. Nevertheless, once activated, you can use ORCOD LabBook Pro in offline mode, though it will periodically ask you to connect to the net in order to verify the state of the license and, in case it could not connect after several attempts, the access to the software would be blocked. In general terms, it is strongly advisable that you always remain connected to the Internet in order to work without any sort of interruption and in a steady way.